Yes. See it as a newspaper:
H1 Headline that tells the reader what the story is about.
H2 Sub subject of the headline.
H3 Sub sub subject…
H2 different Sub subject… etc.
If you’re asking because you want multiple big titles on a page, than just make your H2 tags as big as your H1 Tags. Google doesn’t care how big the titles are. It just wants to understand as good as it can what the subject of a page is.