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No, as long as everything is correctly in place and following best practices.
You stated
>I’m not talking about technical SEO aptness
So I wont go into how some frameworks many not have best practices in place and have inherent issues.
Your site could be pure HTML, or it could be the most sophisticated bleeding edge JS framework. As long as its set up correctly it doesn’t matter. (as long as it isnt a Flash site, hehe)
