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My question is you mention the structure of your campaigns, but what is the differentiator between campaign A&B in terms of what they target in their industry keywords as well as D and E in terms of their products. If you have the same products in some of these campaigns, they could be competing against each other and artificially raising the CPCs.
Also, what is the budget? Depending on that, you could be spreading yourself too thin. PMAX is known for targeting warm campaigns and it’s possible it could be targeting the same search keywords that you are targeting in your search campaigns so check the search themes to be sure.
